Ishida is a Gemischt Quincy residing in Karakura Town. He is a doctor at Karakura Hospital, and a friend of Ichigo Kurosaki. He is a former member of the Wandenreich’s Sternritter with the designation “A” – “Antithesis”, formerly one of Yhwach’s Schutzstaffel, Shuttsushutafferu; German for “Protective Echelon”, Japanese for “Elite/Imperial Guards”), and was once designated as his future successor.

Uryū Ishida is a bespectacled teenager of average height and slender build. He has straight, chin-length black hair framing both sides of his face, and is fair-skinned with blue eyes. In school, Uryū wears the respective school uniform along with a tie. When confronting Hollows, he typically dons white Quincy clothes, with blue stripes representing the Quincy cross, and a mantle.