Isshiki Ōtsutsuki was a member of the Ōtsutsuki clan’s main family and the leader of Kara.

A thousand years ago, Isshiki came to Earth alongside Kaguya with the objective to plant a Tree to harvest its Chakra Fruit. While Kaguya, being lower-ranked, was planned to be sacrificed to create the Chakra Fruit, she instead turned on Isshiki, leaving him on the verge of death after destroying Isshiki’s lower half. Encountering Jigen and not having the strength to implant a Kāma on him, Isshiki devised a desperate plan and shrunk himself to enter the monk’s ear in order to survive his injury by absorbing Jigen’s nutrients. Through time, Isshiki came to control Jigen’s entire body and embed a Kāma onto his host.